Jolie and Pitt - nicknamed "Brangelina" by fans - are one of the best-known couples in Hollywood.
On Monday Angelina filed for "dissolution of marriage", adding the "decision was made for the health of the family".
Their marriage was Pitt's second marriage, having previously wed Friends star Jennifer Aniston, and Jolie's third after Billy Bob Thornton and Jonny Lee Miller.
The pair have also been partners in giving. They were perfect together.